Orianthi Panagaris was born in Adelaide, South Australia, and is of Greek descent. She began playing piano at the age of three and, at the encouragement of her father, moved to acoustic guitar at the age of six. When she was eleven, she took up electric guitar and left her school, Mercedes College, enrolling at Cabra Dominican College. She also attended St Peter's Collegiate Girls' School for a short period. At the age of 15, she turned her focus to writing songs and so began her professional career. She has been playing in bands since the age of 14 and performed in her first stage show for Steve Vai at the age of 15. Orianthi met and jammed with Carlos Santana when she was 18. He invited Orianthi to get up and jam with him at soundcheck then later asked if she would join him on stage that night to jam at his Adelaide concert, Memorial Drive on 30 March 2003.
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